Can you take tramadol with ibuprofen

Tramadol is an opioid analgesic that works on the central nervous system to relieve moderate to severe acute pain. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate acute pain. It can be bought over-the-counter or given to you by a doctor or nurse.

People sometimes mix ibuprofen and opioid painkillers to get better pain relief and reduce swelling and inflammation. Studies have shown that this works. Ibuprofen is what makes the swelling and inflammation go down. Most over-the-counter NSAIDs, such as ibuprofen, acetaminophen, and aspirin, are safe to take with tramadol.

But some over-the-counter medicines sold in pharmacies contain codeine, which is similar to tramadol and shouldn’t be taken at the same time. This combination is more likely to make bad things happen.

When you take these drugs together,

Several studies have shown that combining ibuprofen and opioids is usually the best way to treat severe pain and swelling. Ibuprofen works by stopping the release of certain chemicals that cause pain and swelling. Tramadol works by stopping pain signals from getting to the brain. This makes the pain feel less intense.

There is no known drug interaction between these two medicines, so it is safe to take them together. But you should only use them as your doctor tells you to. Your health care provider is the best person to ask if these medicines are safe for you because they know your medical history, conditions, and other medicines.

Even though both tramadol and ibuprofen can ease pain, they belong to different classes of painkillers because they work in different ways. Because they work in different ways and also help each other out, they can be used together to treat moderate to severe symptoms and help you keep living your normal life.

People often say to take them both at the same time, using ibuprofen for mild to moderate symptoms and tramadol for any pain that comes back. This is because, even though it works better than ibuprofen for treating acute pain, tramadol is an opioid and a controlled substance, so it is often saved and used carefully because it has a high risk of making you dependent.

Can you take tramadol with ibuprofen

Effects that happen often (other than pain relief)

Studies show that taking opioids and ibuprofen together won’t necessarily make you more likely to have reactions or make them worse. It also won’t usually hurt your overall health. But both of them are known to cause problems in the gut. Any of the following side effects could happen if you take this combination:

  • Nausea
  • Vomiting
  • Constipation
  • Stomach discomfort and cramping
  • Indigestion
  • Weakness
  • Dizziness
  • Sleepiness
  • Dry mouth 
  • Respiratory Depression


At the moment, we don’t know of any interactions between ibuprofen and opioids. But there are known interactions between tramadol and other drugs, such as alcohol. Alcohol makes it more likely that your nervous system will react in some way. like feeling sleepy, dizzy, having trouble breathing, and making bad decisions. When taking tramadol, it is always best not to drink alcohol.

Tramadol can affect serotonin, so some people worry that it could cause the blood to thin, especially when it is taken with other drugs that can thin the blood, like ibuprofen. Most studies, though, show that tramadol does not actually affect the blood in any way.

There are several medicines that can change how tramadol works for you. These medicines can also make it more likely that you will have side effects. If you mix an opioid with a drug used to treat depression, anxiety, or other mental health problems, or if you have trouble sleeping, it could be dangerous.

If you are given tramadol, be sure to tell your doctor or pharmacist about any other medicines you are taking. This includes other prescriptions, over-the-counter medicines, herbal remedies, vitamins, supplements, and any other medicines.

There isn’t a lot of research to tell us whether or not it is safe to take Tramadol with herbal remedies and other non-mainstream medicines. These kinds of drugs are not tested as often as prescription drugs are. Most of the time, they aren’t tested to see how they work with other medicines.

What one study says about combining Tramadol and Ibuprofen after a tonsillectomy in a child

A study was done to find out more about how tramadol, acetaminophen, and ibuprofen work together. This clinical trial also looked at their effects when given to healthy volunteers to help kids with pain after they had their tonsils removed.

During this study, ibuprofen and acetaminophen were given by mouth to children right before they had surgery. After the procedure, the children’s adult caretakers gave them oral tramadol, but only if the ibuprofen wasn’t working well enough and the child was in too much pain. During the study, the child’s symptoms were measured using a scale that was given to the parents or responsible party. They were told to measure the child’s symptoms every two hours on the first day after the surgery.

After the study was done, researchers were able to say that a combination of acetaminophen and ibuprofen in doses that are usually given can reduce pain after surgery by up to 65%. They also found out that increasing the amount of ibuprofen and acetaminophen didn’t help much. Lastly, this clinical trial was able to show that adding oral tramadol to the treatment of post-surgery pain was able to make the painkilling effects last longer. Another study came to the same conclusion.

There is evidence from studies that this combination works to reduce inflammation.

Several studies have been done recently to show that taking tramadol with a non-steroidal anti-inflammatory drug like ibuprofen can be more effective than taking either drug alone. In one study, the anti-inflammatory effects of these two drugs were looked at by measuring the levels of C-reactive protein in healthy adult patients after they had surgery to remove an impacted tooth. Patients in this study were split into three equal groups based on the painkillers they took after surgery.

  • In the first group, 100 mg of tramadol was given every eight hours.
  • The people in the second group took 400 mg of ibuprofen every 8 hours.
  • The third group got both drugs together every 8 hours: 50 mg of tramadol and 200 mg of ibuprofen.

The first phase of this study was conducted before the operation. C-reactive proteins were measured in order to exclude any preexisting inflammation that could interfere with the outcome of the study. It was also measured immediately after the procedure and 72 hours into the postoperative period as well. 

The results of the C-reactive protein measurement 72 hours after surgery are as follows.

  • The first group experienced an increase in the c-reactive protein by 123% over the post-surgery baseline. 
  • The second group experienced an increase in the c-reactive protein by 84% over the post-surgery baseline.
  • The third group experienced an increase in the c-reactive protein by 37% over the post-surgery baseline. 

The patients that participated in this study were all healthy adults, including 21 men and 24 women. None of them had any pre-existing inflammatory conditions that would affect the outcome of this clinical trial. Additionally, there were no other significant differences or biological distinctions between any of the adult patients participating in this study. 

The results of this study revealed that while ibuprofen was significantly more effective at treating inflammation than tramadol was by itself; the combination of the two was by far the most effective way to treat post-operative inflammation, and improve your quality of life while recovering from the procedure. 

Risk of Addiction

The potential for abuse and the risk of opioid addiction are high. Although Tramadol has a lower risk than most opioids, it is no exception. When abused, the risk of addiction is still present and associated with an even greater risk of overdose and death. 

The Substance Abuse and Mental Health Services Administration (SAMHSA) sponsored an observational study that told us that the misuse of tramadol was seen in 8.1% of people that took the drug. Anyone abusing this substance is putting themselves at risk of overdose and possibly even death in severe cases. 

The Centers for Disease Control and Prevention report that 51.5% of deaths caused by drug overdose in 2019 in the United States involved a synthetic opioid, including tramadol. That’s more than half of overdose deaths caused by tramadol or other drugs similar to it. 

In order to avoid addiction and overdose, it is important for you to only take an opioid as prescribed by your healthcare provider. It is also important that you do not share your prescription medication with anyone else. 


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